References
Query Results -- Details
MGI Accession ID: MGI:3839069
J Number: J:146998
Other Accession IDs:
Title: Increased energy expenditure and insulin sensitivity in the high bone mass DeltaFosB transgenic mice.
Authors: Rowe GC; Choi CS; Neff L; Horne WC; Shulman GI; Baron R
Journal: Endocrinology
Volume: 150
Issue: 1
Date: 2009 Jan
Year: 2009
Pages: 135-43
Review Status: Peer Reviewed
Abstract:
Obesity and osteoporosis are major health issues affecting millions of individuals. Transgenic mice overexpressing DeltaFosB, an activator protein-1 transcription factor, under the control of the enolase 2 (ENO2) promoter exhibit both an increase in bone density and a decrease in adipose mass. Here we demonstrate that DeltaFosB overexpression increases fatty-acid oxidation and energy expenditure, leading to a decrease in adipocyte size and adipose mass. In addition, the ENO2-DeltaFosB mice exhibit increased insulin sensitivity and glucose tolerance. Targeted overexpression of DeltaFosB in adipocytes using the adipocyte protein 2 promoter failed to induce changes in fat or in bone, showing that the effect on metabolic activity is not due to cell-autonomous effects of DeltaFosB within adipocytes. Detailed analysis of the ENO2-DeltaFosB mice demonstrated that energy expenditure was increased in muscle, independent of locomotor activity. These findings provide evidence that signaling downstream of DeltaFosB is a potential target for not only osteoporosis but also obesity and diabetes.
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