References
Query Results -- Details
MGI Accession ID: MGI:3836830
J Number: J:146145
Other Accession IDs:
Title: Differential regulation of Akt/protein kinase B isoforms during cell cycle progression.
Authors: Yun SJ; Tucker DF; Kim EK; Kim MS; Do KH; Ha JM; Lee SY; Yun J; Kim CD; Birnbaum MJ; Bae SS
Journal: FEBS Lett
Volume: 583
Issue: 4
Date: 2009 Feb 18
Year: 2009
Pages: 685-90
Review Status: Peer Reviewed
Abstract:
Phosphatidylinositol 3-kinase pathways play key regulatory roles in cell cycle progression into S phase. In this study, we demonstrated that Akt1/PKBalpha isoform plays an essential role in G(1)/S transition and proliferation. Cells lacking Akt1/PKBalpha showed an attenuated proliferation as well as G(1)/S transition, whereas cells lacking Akt2/PKBbeta showed normal proliferation and G(1)/S transition. The effect of Akt1/PKBalpha on cell proliferation and G(1)/S transition was completely abolished by swapping pleckstrin homology (PH) domain with that of Akt2/PKBbeta. Finally, full activation of Akt/PKB and cyclin D expression was achieved by the Akt1/PKBalpha or chimeric proteins containing the PH domain of Akt1/PKBalpha indicating that the PH domain of Akt1/PKBalpha provides full kinase activity and is necessary for the G(1)/S transition.
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