References
Query Results -- Details
MGI Accession ID: MGI:3836479
J Number: J:145982
Other Accession IDs:
Title: Collagen VI protects neurons against Abeta toxicity.
Authors: Cheng JS; Dubal DB; Kim DH; Legleiter J; Cheng IH; Yu GQ; Tesseur I; Wyss-Coray T; Bonaldo P; Mucke L
Journal: Nat Neurosci
Volume: 12
Issue: 2
Date: 2009 Feb
Year: 2009
Pages: 119-21
Review Status: Peer Reviewed
Abstract:
Amyloid-beta (Abeta) peptides, widely presumed to cause Alzheimer's disease, increased mouse neuronal expression of collagen VI through a mechanism involving transforming growth factor signaling. Reduction of collagen VI augmented Abeta neurotoxicity, whereas treatment of neurons with soluble collagen VI blocked the association of Abeta oligomers with neurons, enhanced Abeta aggregation and prevented neurotoxicity. These results identify collagen VI as an important component of the neuronal injury response and demonstrate its neuroprotective potential.
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