References
Query Results -- Details
MGI Accession ID: MGI:3835758
J Number: J:145687
Other Accession IDs:
Title: Generation of peripheral B cells occurs via two spatially and temporally distinct pathways.
Authors: Lindsley RC; Thomas M; Srivastava B; Allman D
Journal: Blood
Volume: 109
Issue: 6
Date: 2007 Mar 15
Year: 2007
Pages: 2521-8
Review Status: Peer Reviewed
Abstract:
We have identified a population of newly formed bone marrow (BM) B cells that shares multiple characteristics with late transitional B cells in the spleen. Both late splenic transitional B cells and cells within this uncharacterized BM population expressed the cell-surface phenotype AA4(+) CD23(+), yet the developmental kinetics and the renewal rate of AA4(+) CD23(+) BM B cells mirrored recently formed BM B cells. Further, unlike the least mature B cells in the BM and spleen, AA4(+) CD23(+) BM B cells expressed the homing receptor CD62L, were dependent on the antiapoptotic cytokine receptor BR3 and the tec family kinase Btk, and proliferated in response to IL-4 plus CD40 stimulation. Finally, frequencies of lambda light chain-positive B cells declined among AA4(+) CD23(+) B cells in both the BM and spleen, suggesting that V-gene selection events correlate with CD23 expression in both compartments. These observations indicate that the first step in B-cell maturation occurs in both the BM and the periphery and suggest that recently formed B cells exit the BM as a heterogeneous pool of immature and semimature B cells.
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