References
Query Results -- Details
MGI Accession ID: MGI:3829852
J Number: J:144073
Other Accession IDs:
Title: Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo.
Authors: Galvez AS; Duran A; Linares JF; Pathrose P; Castilla EA; Abu-Baker S; Leitges M; Diaz-Meco MT; Moscat J
Journal: Mol Cell Biol
Volume: 29
Issue: 1
Date: 2009 Jan
Year: 2009
Pages: 104-15
Review Status: Peer Reviewed
Abstract:
Gene alterations in tumor cells that confer the ability to grow under nutrient- and mitogen-deficient conditions constitute a competitive advantage that leads to more-aggressive forms of cancer. The atypical protein kinase C (PKC) isoform, PKCzeta, has been shown to interact with the signaling adapter p62, which is important for Ras-induced lung carcinogenesis. Here we show that PKCzeta-deficient mice display increased Ras-induced lung carcinogenesis, suggesting a new role for this kinase as a tumor suppressor in vivo. We also show that Ras-transformed PKCzeta-deficient lungs and embryo fibroblasts produced more interleukin-6 (IL-6), which we demonstrate here plays an essential role in the ability of Ras-transformed cells to grow under nutrient-deprived conditions in vitro and in a mouse xenograft system in vivo. We also show that PKCzeta represses histone acetylation at the C/EBPbeta element in the IL-6 promoter. Therefore, PKCzeta, by controlling the production of IL-6, is a critical signaling molecule in tumorigenesis.
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