References
Query Results -- Details
MGI Accession ID: MGI:3820521
J Number: J:142184
Other Accession IDs:
Title: Leukocyte migration is regulated by L-selectin endoproteolytic release.
Authors: Venturi GM; Tu L; Kadono T; Khan AI; Fujimoto Y; Oshel P; Bock CB; Miller AS; Albrecht RM; Kubes P; Steeber DA; Tedder TF
Journal: Immunity
Volume: 19
Issue: 5
Date: 2003 Nov
Year: 2003
Pages: 713-24
Review Status: Peer Reviewed
Abstract:
L-selectin mediates lymphocyte migration to peripheral lymph nodes and leukocyte rolling on vascular endothelium during inflammation. One unique feature that distinguishes L-selectin from other adhesion molecules is that it is rapidly cleaved from the cell surface after cellular activation. The biological significance of L-selectin endoproteolytic release was determined by generating gene-targeted mice expressing a modified receptor that was not cleaved from the cell surface. Blocking L-selectin cleavage on antigen-stimulated lymphocytes allowed their continued migration to peripheral lymph nodes and inhibited their short-term redirection to the spleen. Blocking homeostatic L-selectin cleavage also resulted in a constitutive 2-fold increase in overall L-selectin expression by leukocytes. As a result, neutrophils entered the inflamed peritoneum in greater numbers or for a longer duration. Thus, endoproteolytic cleavage regulates both homeostatic and activation-induced changes in cell surface L-selectin density, which directs the migration patterns of activated lymphocytes and neutrophils in vivo.
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