References
Query Results -- Details
MGI Accession ID: MGI:62452
J Number: J:14281
Title: Dwarf grey (dwg).
Authors: Harris B; Davisson MT
Journal: Mouse Genome
Volume: 86
Issue:
Date: 1990
Year: 1990
Pages: 238
Review Status: Peer Reviewed
Abstract:
Full text of Mouse Genome contribution: 4. Dwarf grey (dwg). Dwarf grey (dwg) is a recessive mutation that probably occurred in a linkage cross involving stocks carrying dwarf and T(8;16)17H. The homozygous mutant is characterized by a grey coat, dwarf size and obvious cataracts by 3-4 weeks. The stock is maintained by progeny testing each +/- pair. Dr. Sandy Marks, Jr. of the University of Massachusetts, Department of Anatomy has found that this mutant has an increase in numbers of osteoclasts, a reduced bone mass and a reduction in red pulp area of the spleen as compared to littermate controls. Dr. Wesley Beamer of The Jackson Laboratory found that the mutants have a slightly reduced thyroxine level. The average thyroxin level in mutants (n=19) was 4.82 +/- .27 ug/dl as compared to an average of 5.69 +/- .34 ug/dl in littermate controls (n=13). Linkage crosses are in progress. (B. Harris, Davisson)
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