References
Query Results -- Details
MGI Accession ID: MGI:3814810
J Number: J:140915
Other Accession IDs:
Title: Genetic loci modulating amyloid-beta levels in a mouse model of Alzheimer's disease.
Authors: Ryman D; Gao Y; Lamb BT
Journal: Neurobiol Aging
Volume: 29
Issue: 8
Date: 2008 Aug
Year: 2008
Pages: 1190-8
Review Status: Peer Reviewed
Abstract:
Genetic studies have demonstrated very high heritability for Alzheimer's disease (AD) risk in humans; however, these genetic contributions have proven extremely challenging to map in large studies of AD patients. Processing of the amyloid precursor protein (APP) to produce amyloid-beta (Abeta) peptide is increasingly believed to be of central importance in AD pathogenesis. Intriguingly, mice from the C57BL/6J and DBA2/J inbred strains carrying the R1.40 APP transgene produce identical levels of unprocessed APP, but demonstrate significant, heritable differences in Abeta levels. To identify specific loci responsible for the observed genetic control of Abeta metabolism in this model system, we have performed a whole-genome quantitative trait locus (QTL) mapping experiment on a total of 516 animals from a C57BL/6JxDBA/2J intercross using a dense set of SNP genetic markers. Our studies have identified three loci on mouse chromosomes 1, 2, and 7 showing significant or suggestive associations with brain Abeta levels, several of which contain regions syntenic to previous reports of linkage in human AD.
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