References
Query Results -- Details
MGI Accession ID: MGI:3813789
J Number: J:140445
Other Accession IDs:
Title: AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis.
Authors: Nakagawa M; Ichikawa M; Kumano K; Goyama S; Kawazu M; Asai T; Ogawa S; Kurokawa M; Chiba S
Journal: Blood
Volume: 108
Issue: 10
Date: 2006 Nov 15
Year: 2006
Pages: 3329-34
Review Status: Peer Reviewed
Abstract:
The Notch1-RBP-Jkappa and the transcription factor Runx1 pathways have been independently shown to be indispensable for the establishment of definitive hematopoiesis. Importantly, expression of Runx1 is down-regulated in the para-aortic splanchnopleural (P-Sp) region of Notch1- and Rbpsuh-null mice. Here we demonstrate that Notch1 up-regulates Runx1 expression and that the defective hematopoietic potential of Notch1-null P-Sp cells is successfully rescued in the OP9 culture system by retroviral transfer of Runx1. We also show that Hes1, a known effector of Notch signaling, potentiates Runx1-mediated transactivation. Together with the recent findings in zebrafish, Runx1 is postulated to be a cardinal down-stream mediator of Notch signaling in hematopoietic development throughout vertebrates. Our findings also suggest that Notch signaling may modulate both expression and transcriptional activity of Runx1.
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