References
Query Results -- Details
MGI Accession ID: MGI:3807833
J Number: J:139381
Other Accession IDs:
Title: Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration.
Authors: Singh KK; Park KJ; Hong EJ; Kramer BM; Greenberg ME; Kaplan DR; Miller FD
Journal: Nat Neurosci
Volume: 11
Issue: 6
Date: 2008 Jun
Year: 2008
Pages: 649-58
Review Status: Peer Reviewed
Abstract:
The mechanisms that regulate the pruning of mammalian axons are just now being elucidated. Here, we describe a mechanism by which, during developmental sympathetic axon competition, winning axons secrete brain-derived neurotrophic factor (BDNF) in an activity-dependent fashion, which binds to the p75 neurotrophin receptor (p75NTR) on losing axons to cause their degeneration and, ultimately, axon pruning. Specifically, we found that pruning of rat and mouse sympathetic axons that project to the eye requires both activity-dependent BDNF and p75NTR. p75NTR and BDNF are also essential for activity-dependent axon pruning in culture, where they mediate pruning by directly causing axon degeneration. p75NTR, which is enriched in losing axons, causes axonal degeneration by suppressing TrkA-mediated signaling that is essential for axonal maintenance. These data provide a mechanism that explains how active axons can eliminate less-active, competing axons during developmental pruning by directly promoting p75NTR-mediated axonal degeneration.
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