References
Query Results -- Details
MGI Accession ID: MGI:3806690
J Number: J:138843
Other Accession IDs:
Title: Deficiency of the corpus callosum: incomplete penetrance and substrain differentiation in BALB/c mice.
Authors: Wahlsten D
Journal: J Neurogenet
Volume: 5
Issue: 1
Date: 1989 Jan
Year: 1989
Pages: 61-76
Review Status: Peer Reviewed
Abstract:
In a foundation population of BALB/c mice used to establish a colony at Waterloo in 1977, about 11% of adults showed either total absence or gross deficiency of the corpus callosum. Comparisons between parents and offspring, between progenies of different males, and between 13 separate lines established by full-sib inbreeding showed that variation in the adult corpus callosum reflected a genuine incomplete penetrance in a genetically uniform population. However, after seven generations of inbreeding, a spontaneous change occurred in one line (BALB/cWah 1), resulting in more than 50% of adults with deficient corpus callosum, among which about 20% have complete absence of callosal axons traversing the hemispheres.
