References
Query Results -- Details
MGI Accession ID: MGI:62167
J Number: J:13989
Title: Hippocampal lamination defect = Hld.
Authors: Nowakowski RS
Journal: Mouse News Lett
Volume: 71
Issue:
Date: 1984
Year: 1984
Pages: 35
Review Status: Unreviewed
Abstract:
Full text of MNL contribution: Research News: The laminar organization of the pyramidal cell layer of the hippocampus of BALB/cJ and C57BL/6J differ qualitatively (Barber et al., J. Comp. Neurol., 156: 417-434, 1974; Vaughn et al., J. Comp. Neurol., 173: 41-52, 1977). Analysis of BALB/cJ, BALB/cByJ, C57BL/6J, CB6F1, B6CF1, CB6F2, and the CXB series of RI strains all indicate that this difference is the result of a single autosomal dominant (or semi-dominant) gene of, as yet, undetermined linkage. The SDP in the CXB series is not concordant with any other reported SDP (only CXBE and CXBJ have the C57BL/6 phenotype). The provisional name "Hippocampal lamination defect" and gene symbol, Hld, are proposed for the BALB/c genotype (Nowakowski, J. Neurogenet., submitted). The C57BL/6.J phenotype is characteristic of several inbred strains and, therefore, its genotype should be referred to as wild type. The abnormal lamination of the BALB/c hippocampus appears to be secondary to a defect in neuronal migration which occurs sometime in the first few days after birth (Nowakowski, in press).
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