References
Query Results -- Details
MGI Accession ID: MGI:3798725
J Number: J:137289
Other Accession IDs:
Title: Localization of two new X-linked quantitative trait loci controlling corpus callosum size in the mouse.
Authors: Kusek GK; Wahlsten D; Herron BJ; Bolivar VJ; Flaherty L
Journal: Genes Brain Behav
Volume: 6
Issue: 4
Date: 2007 Jun
Year: 2007
Pages: 359-63
Review Status: Peer Reviewed
Abstract:
Corpus callosum (CC) size is a complex trait, characterized by a gradation of values within a normal range, as well as abnormalities that include a small or totally absent CC. Among inbred mouse strains with defects of the CC, BTBR T(+)tf/J (BTBR) mice have the most extreme phenotype; all animals show total absence of the CC and severe reduction of the hippocampal commissure (HC). In contrast, the BALB/cByJ (BALB) strain has a low frequency of small CC and consistently normal HC. Reciprocal F(1) crosses between BTBR and BALB suggest the presence of X-linked quantitative trait loci (QTLs) affecting CC size. Through linkage analysis of backcross male progeny, we have localized two regions on the X chromosome, having peaks at 68.5 Mb (approximately 29.5 cM) and at 134.5 Mb (approximately 60.5 cM) that are largely responsible for the reciprocal differences, with the BTBR allele showing X-linked dominant inheritance associated with CC defects.
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