References
Query Results -- Details
MGI Accession ID: MGI:3796923
J Number: J:136740
Other Accession IDs:
Title: Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice.
Authors: Adamek A; Jung S; Dienesch C; Laser M; Ertl G; Bauersachs J; Frantz S
Journal: Eur J Pharmacol
Volume: 571
Issue: 1
Date: 2007 Sep 24
Year: 2007
Pages: 51-4
Review Status: Peer Reviewed
Abstract:
Myocardial ischemia induces 5-lipoxygenase (LOX) translocation and leukotriene production in the heart. Leukotrienes increase inflammatory responses and could thereby aggravate ischemic injury. However, the role of lipoxygenase and leukotrienes in cardiac ischemia/reperfusion damage has not been well defined. Therefore, we tested the effect of ischemia reperfusion in mice with targeted deletion of 5-lipoxygenase, the enzyme converting arachidonic acid in leukotrienes. 5-LOX deficient (KO) and wild-type (WT) mice underwent 30 min of coronary artery ligation and 24 h of reperfusion in vivo. In mice with equivalent area at risk, infarct size was not significantly different between WT and KO mice (infarct/area at risk 61.7+/-3.9 vs. 55.8+/-6.6%, WT vs. KO, P=n.s.). However, neutrophil infiltration as well as tumor necrosis factor expression were increased in 5-lipoxygenase deficient mice. In summary, inhibition of 5-lipoxygenase does not affect cardiac ischemia-reperfusion injury but the post-ischemic inflammatory response.
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