References
Query Results -- Details
MGI Accession ID: MGI:3795305
J Number: J:136133
Other Accession IDs:
Title: The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis.
Authors: Duran A; Linares JF; Galvez AS; Wikenheiser K; Flores JM; Diaz-Meco MT; Moscat J
Journal: Cancer Cell
Volume: 13
Issue: 4
Date: 2008 Apr
Year: 2008
Pages: 343-54
Review Status: Peer Reviewed
Abstract:
The balance between cell death and survival, two critical aspects of oncogenic transformation, determines the outcome of tumorigenesis. Nuclear factor-kappaB (NF-kappaB) is a critical regulator of survival; it is induced by the oncogene Ras and, when inhibited, accounts for the cell death response of Ras-transformed cells. Here, we show that the signaling adaptor p62 is induced by Ras, its levels are increased in human tumors, and it is required for Ras-induced survival and transformation. p62-/- mice are resistant to Ras-induced lung adenocarcinomas. p62 is necessary for Ras to trigger IkappaB kinase (IKK) through the polyubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6), and its deficiency produces increased reactive oxygen species (ROS) levels, which account for the enhanced cell death and reduced tumorigenicity of Ras in the absence of p62.
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