References
Query Results -- Details
MGI Accession ID: MGI:3785018
J Number: J:134111
Other Accession IDs:
Title: Genetic control of susceptibility to collagen-induced arthritis in T cell receptor beta-chain transgenic mice.
Authors: Mori L; de Libero G
Journal: Arthritis Rheum
Volume: 41
Issue: 2
Date: 1998 Feb
Year: 1998
Pages: 256-62
Review Status: Peer Reviewed
Abstract:
OBJECTIVE: To study the genes in the mouse background which predispose to the development of collagen-induced arthritis (CIA). METHODS: T cell receptor beta transgenic (TCRbetaL) mice that have a T cell repertoire that predisposes to the development of CIA were used. Classic genetic studies and microsatellite gene mapping were done in (SWR-betaL x DBA/1)F2 hybrid mice. RESULTS: Besides TCRbeta, major histocompatibility complex class II, and Igh-C, at least 2 other genes are absolutely required for CIA development in these mice. A strict association of CIA with the presence of functional complement C5 allele (Hc1) was found, suggesting that Hc1 or a closely linked gene might be one of these essential genes. CONCLUSION: This study provides new evidence of the pathogenetic role of complement C5 in CIA. Furthermore, these transgenic mice may facilitate molecular identification of other genes that predispose to CIA.
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