References
Query Results -- Details
MGI Accession ID: MGI:3774811
J Number: J:131913
Other Accession IDs:
Title: GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model.
Authors: Kouros-Mehr H; Bechis SK; Slorach EM; Littlepage LE; Egeblad M; Ewald AJ; Pai SY; Ho IC; Werb Z
Journal: Cancer Cell
Volume: 13
Issue: 2
Date: 2008 Feb
Year: 2008
Pages: 141-52
Review Status: Peer Reviewed
Abstract:
How breast cancers are able to disseminate and metastasize is poorly understood. Using a hyperplasia transplant system, we show that tumor dissemination and metastasis occur in discrete steps during tumor progression. Bioinformatic analysis revealed that loss of the transcription factor GATA-3 marked progression from adenoma to early carcinoma and onset of tumor dissemination. Restoration of GATA-3 in late carcinomas induced tumor differentiation and suppressed tumor dissemination. Targeted deletion of GATA-3 in early tumors led to apoptosis of differentiated cells, indicating that its loss is not sufficient for malignant conversion. Rather, malignant progression occurred with an expanding GATA-3-negative tumor cell population. These data indicate that GATA-3 regulates tumor differentiation and suppresses tumor dissemination in breast cancer.
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