References
Query Results -- Details
MGI Accession ID: MGI:3770364
J Number: J:129900
Other Accession IDs:
Title: Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6.
Authors: Wittler L; Shin EH; Grote P; Kispert A; Beckers A; Gossler A; Werber M; Herrmann BG
Journal: EMBO Rep
Volume: 8
Issue: 8
Date: 2007 Aug
Year: 2007
Pages: 784-9
Review Status: Peer Reviewed
Abstract:
The vertebral column and skeletal muscles of vertebrates are derived from the paraxial mesoderm, which is laid down initially as two stripes of mesenchymal cells alongside the neural tube and subsequently segmented. Previous work has shown that the wingless-type MMTV integration site family (WNT), fibroblast growth factor- and Delta-Notch signalling pathways control presomitic mesoderm (psm) formation and segmentation. Here, we show that the expression of mesogenin 1, a basic helix-loop-helix transcription factor, which is essential for psm maturation, is regulated by synergism between WNT signalling and the T-box 6 transcription factor, involving a feed-forward control mechanism. These findings emphasize the crucial role of WNT signalling in the control of psm formation, maturation and segmentation.
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