References
Query Results -- Details
MGI Accession ID: MGI:3770000
J Number: J:129704
Other Accession IDs:
Title: Protein composition determines the anti-atherogenic properties of HDL in transgenic mice.
Authors: Schultz JR; Verstuyft JG; Gong EL; Nichols AV; Rubin EM
Journal: Nature
Volume: 365
Issue: 6448
Date: 1993 Oct 21
Year: 1993
Pages: 762-4
Review Status: Peer Reviewed
Abstract:
High-density lipoprotein (HDL) contains two major proteins, apolipoprotein A-I (apoA-I) and apolipoprotein A-II (apoA-II), comprising about 70% and 20% of the total HDL protein mass, respectively. HDL exists in human plasma in two main forms, one containing apoA-I with apoA-II (AI/AII-HDL) and another containing apoA-I without apoA-II (AI-HDL). A strong inverse relationship exists between total plasma HDL concentration and atherosclerosis, but the results of studies examining the relationship between AI-HDL and AI/AII-HDL and atherosclerosis have been conflicting. To determine whether these two HDL populations have different effects on atherogenesis, human apoA-I (AI) and human apoA-I and apoA-II (AI/AII) transgenic mice were produced in an atherosclerosis-susceptible strain. Following an atherogenic diet, despite similar total cholesterol and HDL cholesterol concentrations, the area of atherogenic lesions in the AI/AII mice was 15-fold greater than in the AI animals. These studies show that the protein composition of HDL significantly affects its role in atherogenesis and that AI-HDL is more antiatherogenic than AI/AII-HDL.
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