References
Query Results -- Details
MGI Accession ID: MGI:3769645
J Number: J:129554
Other Accession IDs:
Title: Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes.
Authors: Liu Y; Michael MD; Kash S; Bensch WR; Monia BP; Murray SF; Otto KA; Syed SK; Bhanot S; Sloop KW; Sullivan JM; Reifel-Miller A
Journal: Endocrinology
Volume: 148
Issue: 2
Date: 2007 Feb
Year: 2007
Pages: 683-92
Review Status: Peer Reviewed
Abstract:
Adiponectin/adiponectin receptors (AdipoR) are involved in energy homeostasis and inflammatory pathways. To investigate the role of AdipoR2 in metabolic control, we studied the lipid and glucose metabolic phenotypes in AdipoR2-deficient mice. AdipoR2 deletion diminished high-fat diet-induced dyslipidemia and insulin resistance yet deteriorated glucose homeostasis as high-fat feeding continued, which resulted from the failure of pancreatic beta-cells to adequately compensate for the moderate insulin resistance. A defect in the AdipoR2 gene may represent a mechanism underlying the etiology of certain subgroups of type 2 diabetic patients who eventually develop overt diabetes, whereas other obese patients do not.
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