References
Query Results -- Details
MGI Accession ID: MGI:3768004
J Number: J:128772
Other Accession IDs:
Title: Normal induction but accelerated decay of LTP in APP + PS1 transgenic mice.
Authors: Gureviciene I; Ikonen S; Gurevicius K; Sarkaki A; van Groen T; Pussinen R; Ylinen A; Tanila H
Journal: Neurobiol Dis
Volume: 15
Issue: 2
Date: 2004 Mar
Year: 2004
Pages: 188-95
Review Status: Peer Reviewed
Abstract:
Mice carrying mutated human APPswe and PS1 (A246E) transgenes (A/P mice) show age-dependent memory impairment in hippocampus-dependent tasks. Moreover, the mice show normal learning in the water maze within a day but impairment across days. We recorded LTP in a slice preparation (CA1) and in chronically implanted animals (dentate gyrus, or DG) at 17-18 months of age. The genotypes did not differ in the basal synaptic transmission. Also, LTP induction and its maintenance over 60 min did not differ between A/P and control mice. However, the fEPSP enhancement in vivo decayed to 77% of its maximum in 24 h in A/P mice while remaining at 96% in control mice. The time course of the LTP decay in the A/P mice corresponds to their behavioral impairment and indicates that Abeta accumulation in the dentate gyrus may interfere with the signal transduction pathways responsible for memory consolidation.
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