References
Query Results -- Details
MGI Accession ID: MGI:3723560
J Number: J:125114
Other Accession IDs:
Title: OBF-1 is essential for the generation of antibody-secreting cells and the development of autoimmunity in MRL-lpr mice.
Authors: Zuo J; Ge H; Zhu G; Matthias P; Sun J
Journal: J Autoimmun
Volume: 29
Issue: 2-3
Date: 2007 September - November
Year: 2007
Pages: 87-96
Review Status: Peer Reviewed
Abstract:
As reported previously, the lack of the transcriptional co-activator OBF-1 prevented development of autoimmunity in Aiolos knockout mice. To further investigate the role and mechanism of OBF-1 in autoimmunity, we crossed OBF-1 null mice with MRL-lpr mice and generated OBF-1-deficent MRL-lpr mice. OBF-1 deletion abrogated all autoantibodies in the MRL-lpr mice, including anti-dsDNA Ab and anti-Sm Ab. The failure to produce autoantibodies was not related to development of immature or mature B cells, but correlated with severely reduced antibody-secreting cells (ASCs). The loss of OBF-1 protected against hypergammaglobulinemia, immune complex deposition, glomerulonephritis, and early mortality in MRL-lpr mice. In addition, accumulation of CD4(-)CD8(-)B220(+)CD3(+) T cells that characteristically develop in Fas mutation mice were markedly reduced in MRL-lpr mice without OBF-1. These results identify OBF-1 as a critical gene in the development of autoantibodies and reveal an essential role for OBF-1 in the generation of antibody/autoantibody-secreting cells in vivo.
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