References
Query Results -- Details
MGI Accession ID: MGI:3721330
J Number: J:124321
Other Accession IDs:
Title: Disruption of Tumor Cell Adhesion Promotes Angiogenic Switch and Progression to Micrometastasis in RAF-Driven Murine Lung Cancer.
Authors: Ceteci F; Ceteci S; Karreman C; Kramer BW; Asan E; Gotz R; Rapp UR
Journal: Cancer Cell
Volume: 12
Issue: 2
Date: 2007 Aug 14
Year: 2007
Pages: 145-159
Review Status: Peer Reviewed
Abstract:
Progression of non-small-cell lung cancer (NSCLC) to metastasis is poorly understood. Two genetic approaches were used to evaluate the role of adherens junctions in a C-RAF driven mouse model for NSCLC: conditional ablation of the cdh1 gene and expression of dominant-negative (dn) E-cadherin. Disruption of E-cadherin caused massive formation of intratumoral vessels that was reversible in the early phase of induction. Vascularized tumors grew more rapidly, developed invasive fronts, and gave rise to micrometastasis. beta-catenin was identified as a critical effector of E-cadherin disruption leading to upregulation of VEGF-A and VEGF-C. In vivo, lung tumor cells with disrupted E-cadherin expressed beta-catenin target genes normally found in other endodermal lineages suggesting that reprogramming may be involved in metastatic progression.
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