References
Query Results -- Details
MGI Accession ID: MGI:3714254
J Number: J:122420
Other Accession IDs:
Title: Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs.
Authors: Veerman KM; Williams MJ; Uchimura K; Singer MS; Merzaban JS; Naus S; Carlow DA; Owen P; Rivera-Nieves J; Rosen SD; Ziltener HJ
Journal: Nat Immunol
Volume: 8
Issue: 5
Date: 2007 May
Year: 2007
Pages: 532-9
Review Status: Peer Reviewed
Abstract:
P-selectin glycoprotein ligand 1 (PSGL-1) is central to the trafficking of immune effector cells to areas of inflammation through direct interactions with P-selectin, E-selectin and L-selectin. Here we show that PSGL-1 was also required for efficient homing of resting T cells to secondary lymphoid organs but functioned independently of selectin binding. PSGL-1 mediated an enhanced chemotactic T cell response to the secondary lymphoid organ chemokines CCL21 and CCL19 but not to CXCL12 or to inflammatory chemokines. Our data show involvement of PSGL-1 in facilitating the entry of T cells into secondary lymphoid organs, thereby demonstrating the bifunctional nature of this molecule.
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