References
Query Results -- Details
MGI Accession ID: MGI:3712607
J Number: J:121897
Other Accession IDs:
Title: Restoration of cone vision in a mouse model of achromatopsia.
Authors: Alexander JJ; Umino Y; Everhart D; Chang B; Min SH; Li Q; Timmers AM; Hawes NL; Pang JJ; Barlow RB; Hauswirth WW
Journal: Nat Med
Volume: 13
Issue: 6
Date: 2007 Jun
Year: 2007
Pages: 685-7
Review Status: Peer Reviewed
Abstract:
Loss of cone function in the central retina is a pivotal event in the development of severe vision impairment for many prevalent blinding diseases. Complete achromatopsia is a genetic defect resulting in cone vision loss in 1 in 30,000 individuals. Using adeno-associated virus (AAV) gene therapy, we show that it is possible to target cones and rescue both the cone-mediated electroretinogram response and visual acuity in the Gnat2 ( cpfl3 ) mouse model of achromatopsia.
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