References
Query Results -- Details
MGI Accession ID: MGI:3706450
J Number: J:120368
Other Accession IDs:
Title: Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR.
Authors: Passino MA; Adams RA; Sikorski SL; Akassoglou K
Journal: Science
Volume: 315
Issue: 5820
Date: 2007 Mar 30
Year: 2007
Pages: 1853-6
Review Status: Peer Reviewed
Abstract:
Differentiation of hepatic stellate cells (HSCs) to extracellular matrix- and growth factor-producing cells supports liver regeneration through promotion of hepatocyte proliferation. We show that the neurotrophin receptor p75NTR, a tumor necrosis factor receptor superfamily member expressed in HSCs after fibrotic and cirrhotic liver injury in humans, is a regulator of liver repair. In mice, depletion of p75NTR exacerbated liver pathology and inhibited hepatocyte proliferation in vivo. p75NTR-/- HSCs failed to differentiate to myofibroblasts and did not support hepatocyte proliferation. Moreover, inhibition of p75NTR signaling to the small guanosine triphosphatase Rho resulted in impaired HSC differentiation. Our results identify signaling from p75NTR to Rho as a mechanism for the regulation of HSC differentiation to regeneration-promoting cells that support hepatocyte proliferation in the diseased liver.
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