References
Query Results -- Details
MGI Accession ID: MGI:3702218
J Number: J:119437
Other Accession IDs:
Title: Deficiency of small GTPase Rac2 affects T cell activation.
Authors: Yu H; Leitenberg D; Li B; Flavell RA
Journal: J Exp Med
Volume: 194
Issue: 7
Date: 2001 Oct 1
Year: 2001
Pages: 915-26
Review Status: Peer Reviewed
Abstract:
Rac2 is a hematopoietic-specific GTPase acting as a molecular switch to mediate both transcriptional activation and cell morphological changes. We have examined the effect of Rac2 deficiency during T cell activation. In Rac2(-/-) T cells, proliferation was reduced upon stimulation with either plate-bound anti-CD3 or T cell receptor-specific antigen. This defect is accompanied with decreased activation of mitogen activated protein kinase extracellular signal-regulated kinase (ERK)1/2 and p38, and reduced Ca(2)+ mobilization. TCR stimulation-induced actin polymerization is also reduced. In addition, anti-CD3 cross-linking-induced T cell capping is reduced compared with wild-type T cells. These results indicate that Rac2 is important in mediating both transcriptional and cytoskeletal changes during T cell activation. The phenotypic similarity of Rac2(-/-) to Vav(-/-) cells implicates Rac2 as a downstream mediator of Vav signaling.
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