References
Query Results -- Details
MGI Accession ID: MGI:3699683
J Number: J:118500
Other Accession IDs:
Title: Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by Mycobacterium bovis BCG Pleurisy.
Authors: D'Avila H; Almeida PE; Roque NR; Castro-Faria-Neto HC; Bozza PT
Journal: Infect Immun
Volume: 75
Issue: 3
Date: 2007 Mar
Year: 2007
Pages: 1507-11
Review Status: Peer Reviewed
Abstract:
An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of eotaxin or CCR3 drastically inhibited BCG-induced eosinophil accumulation and lipid body formation, indicating that BCG-induced eosinophil recruitment and activation is largely dependent of TLR2-mediated eotaxin generation.
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