References
Query Results -- Details
MGI Accession ID: MGI:3692050
J Number: J:115663
Other Accession IDs:
Title: Dual roles of the C-terminal Src kinase (Csk) during developmental vascularization.
Authors: Duan LJ; Imamoto A; Fong GH
Journal: Blood
Volume: 103
Issue: 4
Date: 2004 Feb 15
Year: 2004
Pages: 1370-2
Review Status: Peer Reviewed
Abstract:
Here we report that C-terminal Src kinase (Csk), a tyrosine kinase that negatively regulates the activity of Src and related kinases, is important for vascular development. In Csk(-/-) embryos, although vascular tubules were formed and organized into capillary-like networks during the initial genesis of blood vessels, the vessels failed to engage in normal sprout formation. In chimeric embryos containing both wild-type and Csk(-/-) cells, the presence of wild-type cells enabled Csk(-/-) endothelial cells to participate in branching morphogenesis. We suggest that wild-type cells may have supplied an angiogenic factor absent in Csk(-/-) cells. Despite the partial rescue of vascular development in chimeric embryos, the embryos failed to form vitelline vessels and died at E9.5. These results indicate that Csk is required both for angiogenic sprouting and vascular remodeling.
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