References
Query Results -- Details
MGI Accession ID: MGI:3691906
J Number: J:115538
Other Accession IDs:
Title: Control of New World cutaneous leishmaniasis is IL-12 independent but STAT4 dependent.
Authors: Buxbaum LU; Uzonna JE; Goldschmidt MH; Scott P
Journal: Eur J Immunol
Volume: 32
Issue: 11
Date: 2002 Nov
Year: 2002
Pages: 3206-15
Review Status: Peer Reviewed
Abstract:
Leishmania mexicana, a New World protozoan parasite, induces small, chronic, but non-progressive lesions in C57BL/6 (B6) mice. In this study we investigated the role of IL-12, and subsequent Th1 factors, in controlling cutaneous L. mexicana infection. IL-12 treatment failed to promote disease resolution, suggesting that the inability of mice to heal is not related to a deficiency of endogenous IL-12 production. Surprisingly, L. mexicana-induced cutaneous lesions in wild-type and IL-12p40-deficient mice were indistinguishable, with similar parasite burdens, immune responses, and lesion histopathology. In contrast, iNOS, IFN-gamma, and STAT4-deficient mice developed progressive disease and uncontrolled parasite growth. These results differ dramatically from L. major infection, in which IL-12p40-deficient mice are highly susceptible, with very rapid lesion growth, very large parasite burdens, and the development of a strong Th2 response. These data uncover the existence of an alternate IFN-gamma and iNOS pathway for control of Leishmania lesions, which is IL-12 independent, but which unexpectedly requires STAT4.
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