References
Query Results -- Details
MGI Accession ID: MGI:3691733
J Number: J:115454
Other Accession IDs:
Title: Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity.
Authors: Chen L; Taishi P; Duricka D; Krueger JM
Journal: Brain Res Mol Brain Res
Volume: 129
Issue: 1-2
Date: 2004 Oct 22
Year: 2004
Pages: 179-84
Review Status: Peer Reviewed
Abstract:
Prolactin (PRL) and vasoactive intestinal polypeptide (VIP) mRNA levels were elevated in the brainstem of neuronal nitric oxide synthase (nNOS) gene knockout (KO) mice compared to the levels in nNOS control mice. In addition, PRL mRNA levels increased in the hypothalamus and the brainstem of nNOS control mice after administration of 7-nitro-indazole (7-NI), a relatively selective nNOS inhibitor. The results suggest that NO inhibits PRL. No differences in the genes measured were observed in inducible NOS KO mice.
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