References
Query Results -- Details
MGI Accession ID: MGI:3656192
J Number: J:112390
Other Accession IDs:
Title: Ablation of CD22 in ligand-deficient mice restores B cell receptor signaling.
Authors: Collins BE; Smith BA; Bengtson P; Paulson JC
Journal: Nat Immunol
Volume: 7
Issue: 2
Date: 2006 Feb
Year: 2006
Pages: 199-206
Review Status: Peer Reviewed
Abstract:
CD22 is a negative regulator of B cell signaling, an activity modulated by its interaction with glycan ligands containing alpha2-6-linked sialic acids. B cells deficient in the enzyme (ST6Gal I) that forms the CD22 ligand show suppressed BCR signaling. Here we report that mice deficient in both CD22 and its ligand (Cd22-/- St6gal1-/- mice) showed restored B cell receptor (BCR) signaling, suggesting that the suppressed signaling of St6gal1-/- cells is mediated through CD22. Coincident with suppressed BCR signaling, B cells lacking ST6Gal I showed a net redistribution of the BCR to clathrin-rich microdomains containing most of the CD22, resulting in a twofold increase in the localization of CD22 together with the BCR. These studies suggest an important function for the CD22-ligand interaction in regulating BCR signaling and microdomain localization.
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