References
Query Results -- Details
MGI Accession ID: MGI:3653326
J Number: J:111243
Other Accession IDs:
Title: Sustained astrocytic clusterin expression improves remodeling after brain ischemia.
Authors: Imhof A; Charnay Y; Vallet PG; Aronow B; Kovari E; French LE; Bouras C; Giannakopoulos P
Journal: Neurobiol Dis
Volume: 22
Issue: 2
Date: 2006 May
Year: 2006
Pages: 274-83
Review Status: Peer Reviewed
Abstract:
Clusterin is a glycoprotein highly expressed in response to tissue injury. Using clusterin-deficient (Clu-/-) mice, we investigated the role of clusterin after permanent middle cerebral artery occlusion (MCAO). In wild-type (WT) mice, clusterin mRNA displayed a sustained increase in the peri-infarct area from 14 to 30 days post-MCAO. Clusterin transcript was still present up to 90 days post-ischemia in astrocytes surrounding the core infarct. Western blot analysis also revealed an increase of clusterin in the ischemic hemisphere of WT mice, which culminates up to 30 days post-MCAO. Concomitantly, a worse structural restoration and higher number of GFAP-reactive astrocytes in the vicinity of the infarct scar were observed in Clu-/- as compared to WT mice. These findings go beyond previous data supporting a neuroprotective role of clusterin in early ischemic events in that they demonstrate that this glycoprotein plays a central role in the remodeling of ischemic damage.
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