References
Query Results -- Details
MGI Accession ID: MGI:3640879
J Number: J:110683
Other Accession IDs:
Title: Primary B cell development is impaired in mice with defects of the pituitary/thyroid axis.
Authors: Montecino-Rodriguez E; Clark RG; Powell-Braxton L; Dorshkind K
Journal: J Immunol
Volume: 159
Issue: 6
Date: 1997 Sep 15
Year: 1997
Pages: 2712-9
Review Status: Peer Reviewed
Abstract:
There has been considerable speculation that hormones produced in the anterior pituitary gland act as positive regulators of primary B cell development in the bone marrow. In order to identify endocrine factors that have such a role, B cell differentiation was examined in a panel of mice with genetic mutations that result in compromised production of one or more anterior pituitary hormones. This analysis demonstrated that the frequency of B lineage cells is significantly reduced in the dwarf and hypothyroid strains of mice, which have defects in the pituitary/thyroid axis, and that the production of normal numbers of pre-B cells is particularly dependent upon thyroid hormones. B cell development was normal in Little and IGF-I knockout animals, which have defects in the production of growth hormone and/or insulin-like growth factor I. The dependence of B lymphopoiesis on thyroid hormones appeared to be specific for that lineage, as myelopoiesis and thymopoiesis were normal in dwarf and hypothyroid mice. In addition to describing a specific endocrine hormone involved in the regulation of B cell development, these data provide evidence that normal production of bone marrow B lineage cells is dependent on extramedullary signals.
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