References
Query Results -- Details
MGI Accession ID: MGI:3639073
J Number: J:110081
Other Accession IDs:
Title: Improved functional outcome after spinal cord injury in iNOS-deficient mice.
Authors: Isaksson J; Farooque M; Olsson Y
Journal: Spinal Cord
Volume: 43
Issue: 3
Date: 2005 Mar
Year: 2005
Pages: 167-70
Review Status: Peer Reviewed
Abstract:
STUDY DESIGN: Functional outcome was evaluated following experimental compression-type spinal cord injury (SCI) in wild-type mice and knockout mice, lacking the inducible nitric oxide synthase (iNOS) gene. OBJECTIVES: To evaluate the role of the nitric oxide generating enzyme iNOS in SCI. METHODS: The experimental animals were subjected to an extradural compression of the thoracic spinal cord. Functional outcome was studied during the first 2 weeks post-injury using a scoring system for assessment of hind limb motor function. RESULTS: Injury resulted in initial paraplegia followed by gradual improvement of motor function in most cases. Mice lacking the iNOS gene (iNOS-/-) clearly tended to have a better functional outcome than wild-type mice. The difference was significant on day 14 after injury. CONCLUSION: In accordance with a few earlier experimental studies, showing beneficial effects of pharmacological iNOS inhibition, the present report would indicate a destructive influence of iNOS following spinal cord trauma.
Additional Information:
