References
Query Results -- Details
MGI Accession ID: MGI:3630030
J Number: J:109854
Other Accession IDs:
Title: Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells.
Authors: Schluns KS; Williams K; Ma A; Zheng XX; Lefrancois L
Journal: J Immunol
Volume: 168
Issue: 10
Date: 2002 May 15
Year: 2002
Pages: 4827-31
Review Status: Peer Reviewed
Abstract:
IL-15 and IL-15Ralpha are required for generation of memory-phenotype CD8 T cells in unimmunized mice. However, the role of IL-15 in primary expansion and generation of Ag-specific memory CD8 T cells in vivo has not been investigated. We characterized the CD8 T cell response against vesicular stomatitis virus (VSV) in IL-15(-/-) and IL-15Ralpha(-/-) mice. Surprisingly, IL-15 was required for primary expansion of VSV-specific CD8 T cells. The generation of VSV-specific memory CD8 T cells was also impaired without IL-15 signaling, and this defect correlated with a decrease in memory CD8 T cell turnover. Despite minimal proliferation without IL-15, a subset of memory cells survived long-term. IL-15Ralpha expression was low on naive CD8 T cells, up-regulated on Ag-specific effector cells, and sustained on memory cells. Thus, IL-15 was important for the generation and the subsequent maintenance of antiviral memory CD8 T cells.
