References
Query Results -- Details
MGI Accession ID: MGI:3629340
J Number: J:109590
Other Accession IDs:
Title: A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.
Authors: Sakaguchi M; Shingo T; Shimazaki T; Okano HJ; Shiwa M; Ishibashi S; Oguro H; Ninomiya M; Kadoya T; Horie H; Shibuya A; Mizusawa H; Poirier F; Nakauchi H; Sawamoto K; Okano H
Journal: Proc Natl Acad Sci U S A
Volume: 103
Issue: 18
Date: 2006 May 2
Year: 2006
Pages: 7112-7
Review Status: Peer Reviewed
Abstract:
In the subventricular zone of the adult mammalian forebrain, neural stem cells (NSCs) reside and proliferate to generate young neurons. We screened factors that promoted the proliferation of NSCs in vitro by a recently developed proteomics technique, the ProteinChip system. In this screen, we identified a soluble carbohydrate-binding protein, Galectin-1, as a candidate. We show herein that Galectin-1 is expressed in a subset of slowly dividing subventricular zone astrocytes, which includes the NSCs. Based on results from intraventricular infusion experiments and phenotypic analyses of knockout mice, we demonstrate that Galectin-1 is an endogenous factor that promotes the proliferation of NSCs in the adult brain.
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