References
Query Results -- Details
MGI Accession ID: MGI:59415
J Number: J:10973
Other Accession IDs:
Title: An autosomal recessive gene that delays expression of lupus in BXSB mice.
Authors: Kofler R; McConahey PJ; Duchosal MA; Balderas RS; Theofilopoulos AN; Dixon FJ
Journal: J Immunol
Volume: 146
Issue: 4
Date: 1991 Feb 15
Year: 1991
Pages: 1375-9
Review Status: Peer Reviewed
Abstract:
We report the generation and serologic, cellular, histologic, and genetic characteristics of a BXSB/MpJScr substrain, termed BXSB/MpJScr-ll/ll, that has lost early-life male lupus disease. Classic genetic analysis suggested that delayed disease expression results from the action of a single autosomal recessive gene. This putative gene, referred to as ll (long-lived), causes a significant delay in expression of autoimmune serology (total serum IgG and anti-nuclear antibodies levels), monocytosis, and of immune complex-mediated histopathologic changes such as glomerulonephritis, arteritis, and myocardial infarction. Presumably as a consequence of the delayed immunopathology male BXSB/MpJScr-ll/ll mice live three to four times longer than regular BXSB/MpJScr. This strain might be useful for analysis of single genes responsible for severe autoimmune disease expression.
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