References
Query Results -- Details
MGI Accession ID: MGI:3623707
J Number: J:108336
Other Accession IDs:
Title: Genetics of early mammalian folliculogenesis.
Authors: Choi Y; Rajkovic A
Journal: Cell Mol Life Sci
Volume: 63
Issue: 5
Date: 2006 Mar
Year: 2006
Pages: 579-90
Review Status: Peer Reviewed
Abstract:
Early ovarian folliculogenesis begins with the breakdown of germ cell clusters and formation of primordial follicles. Primordial follicles are the smallest ovarian follicle units continuously recruited to grow into primary and more advanced ovarian follicles. Genes expressed in the germ cells such as Figla, Nobox, Kit and Ntrk2, as well as genes expressed in the surrounding somatic cells such as Foxl2, Kitl and Ngf, play critical functions during early folliculogenesis. Transgenic mice continue to provide important insights into the genetic pathways that regulate early mammalian folliculogenesis. Genes critical in early folliculogenesis are important determinants of reproductive life span and represent candidate genes for human ovarian failure.
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