References
Query Results -- Details
MGI Accession ID: MGI:3622578
J Number: J:107943
Other Accession IDs:
Title: The role of Rac1 and Rac2 in bacterial killing.
Authors: Koh AL; Sun CX; Zhu F; Glogauer M
Journal: Cell Immunol
Volume: 235
Issue: 2
Date: 2005 Jun
Year: 2005
Pages: 92-7
Review Status: Peer Reviewed
Abstract:
The small Rho guanosine triphosphatases (GTPases) Rac1 and Rac2 have distinct roles in regulating neutrophil chemotaxis; however, little is known about their possible unique roles in mediating bacterial killing. To elucidate the relative roles of Rac1 and Rac2 in regulating neutrophil-mediated bacterial killing, we utilized the previously described mice model in which mouse neutrophils are deficient in either Rac1, Rac2, or both isoforms. We demonstrate here that while both Rac isoforms are required for normal neutrophil chemotaxis and bacterial killing, they have non-overlapping roles in bacterial phagocytosis and NADPH oxidase function.
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