References
Query Results -- Details
MGI Accession ID: MGI:3620450
J Number: J:107244
Other Accession IDs:
Title: Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice.
Authors: Koike H; Arguello PA; Kvajo M; Karayiorgou M; Gogos JA
Journal: Proc Natl Acad Sci U S A
Volume: 103
Issue: 10
Date: 2006 Mar 7
Year: 2006
Pages: 3693-7
Review Status: Peer Reviewed
Abstract:
Disrupted-In-Schizophrenia (DISC1) is a leading candidate schizophrenia susceptibility gene. Here, we describe a deletion variant in mDisc1 specific to the 129S6/SvEv strain that introduces a termination codon at exon 7, abolishes production of the full-length protein, and impairs working memory performance when transferred to the C57BL/6J genetic background. Our findings provide insights into how DISC1 variation contributes to schizophrenia susceptibility in humans and the behavioral divergence between 129S6/SvEv and C57BL/6J mouse strains and have implications for modeling psychiatric diseases in mice.
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