References
Query Results -- Details
MGI Accession ID: MGI:3619085
J Number: J:106600
Other Accession IDs:
Title: Heme oxygenase-1 protects against vascular constriction and proliferation.
Authors: Duckers HJ; Boehm M; True AL; Yet SF; San H; Park JL; Clinton Webb R; Lee ME; Nabel GJ; Nabel EG
Journal: Nat Med
Volume: 7
Issue: 6
Date: 2001 Jun
Year: 2001
Pages: 693-8
Review Status: Peer Reviewed
Abstract:
Heme oxygenase (HO-1, encoded by Hmox1) is an inducible protein activated in systemic inflammatory conditions by oxidant stress. Vascular injury is characterized by a local reparative process with inflammatory components, indicating a potential protective role for HO-1 in arterial wound repair. Here we report that HO-1 directly reduces vasoconstriction and inhibits cell proliferation during vascular injury. Expression of HO-1 in arteries stimulated vascular relaxation, mediated by guanylate cyclase and cGMP, independent of nitric oxide. The unexpected effects of HO-1 on vascular smooth muscle cell growth were mediated by cell-cycle arrest involving p21Cip1. HO-1 reduced the proliferative response to vascular injury in vivo; expression of HO-1 in pig arteries inhibited lesion formation and Hmox1-/- mice produced hyperplastic arteries compared with controls. Induction of the HO-1 pathway moderates the severity of vascular injury by at least two adaptive mechanisms independent of nitric oxide, and is a potential therapeutic target for diseases of the vasculature.
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