References
Query Results -- Details
MGI Accession ID: MGI:59219
J Number: J:10774
Other Accession IDs:
Title: Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.
Authors: Li S; Crenshaw EB 3d; Rawson EJ; Simmons DM; Swanson LW; Rosenfeld MG
Journal: Nature
Volume: 347
Issue: 6293
Date: 1990 Oct 11
Year: 1990
Pages: 528-33
Review Status: Peer Reviewed
Abstract:
Mutations at the mouse dwarf locus (dw) interrupt the normal development of the anterior pituitary gland, resulting in the loss of expression of growth hormone, prolactin and thyroid-stimulating hormone, and hypoplasia of their respective cell types. Disruptions in the gene encoding the POU-domain transcription factor, Pit-1, occur in both characterized alleles of the dwarf locus. The data indicate that Pit-1 is necessary for the specification of the phenotype of three cell types in the anterior pituitary, and directly link a transcription factor to commitment and progression events in mammalian organogenesis.
Additional Information:
