References
Query Results -- Details
MGI Accession ID: MGI:3618445
J Number: J:106400
Other Accession IDs:
Title: Involvement of 5-lipoxygenase in spinal cord injury.
Authors: Genovese T; Mazzon E; Rossi A; Di Paola R; Cannavo G; Muia C; Crisafulli C; Bramanti P; Sautebin L; Cuzzocrea S
Journal: J Neuroimmunol
Volume: 166
Issue: 1-2
Date: 2005 Sep
Year: 2005
Pages: 55-64
Review Status: Peer Reviewed
Abstract:
A traumatic spinal cord injury (SCI) induces a sequelae of events which conduce biochemical and cellular alterations. Here we compare the degree of spinal cord injury caused by the application of vascular clips, in mice lacking the 5-lipoxygenase and in the corresponding wild-type mice. Biochemical, immunohistochemical and functional studies revealed respectively an increase of neutrophils infiltration, of IL-1beta, TNF-alpha immunoreactivity, apoptosis (measured by Annexin-V staining) and loss of hind legs movement in SCI operated 5-LO wild-type mice. In contrast, the degree of (1) neutrophil infiltration at different time points, (2) cytokine expression (TNF-alpha and IL-1beta), (3) histological damage, (4) apoptosis, was markedly reduced in the tissues obtained from SCI operated 5-LO deficient mice and (5) the motor recovery was ameliorated.
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