References
Query Results -- Details
MGI Accession ID: MGI:3616525
J Number: J:105800
Other Accession IDs:
Title: Natural regulatory T cells control the development of atherosclerosis in mice.
Authors: Ait-Oufella H; Salomon BL; Potteaux S; Robertson AK; Gourdy P; Zoll J; Merval R; Esposito B; Cohen JL; Fisson S; Flavell RA; Hansson GK; Klatzmann D; Tedgui A; Mallat Z
Journal: Nat Med
Volume: 12
Issue: 2
Date: 2006 Feb
Year: 2006
Pages: 178-80
Review Status: Peer Reviewed
Abstract:
Atherosclerosis is an immunoinflammatory disease elicited by accumulation of lipids in the artery wall and leads to myocardial infarction and stroke. Here, we show that naturally arising CD4(+)CD25(+) regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens, are powerful inhibitors of atherosclerosis in several mouse models. These results provide new insights into the immunopathogenesis of atherosclerosis and could lead to new therapeutic approaches that involve immune modulation using regulatory T cells.
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