References
Query Results -- Details
MGI Accession ID: MGI:3609457
J Number: J:103424
Other Accession IDs:
Title: The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development.
Authors: Hornstein E; Mansfield JH; Yekta S; Hu JK; Harfe BD; McManus MT; Baskerville S; Bartel DP; Tabin CJ
Journal: Nature
Volume: 438
Issue: 7068
Date: 2005 Dec 1
Year: 2005
Pages: 671-4
Review Status: Peer Reviewed
Abstract:
MicroRNAs (miRNAs) are an abundant class of gene regulatory molecules (reviewed in refs 1, 2). Although computational work indicates that miRNAs repress more than a third of human genes, their roles in vertebrate development are only now beginning to be determined. Here we show that miR-196 acts upstream of Hoxb8 and Sonic hedgehog (Shh) in vivo in the context of limb development, thereby identifying a previously observed but uncharacterized inhibitory activity that operates specifically in the hindlimb. Our data indicate that miR-196 functions in a fail-safe mechanism to assure the fidelity of expression domains that are primarily regulated at the transcriptional level, supporting the idea that many vertebrate miRNAs may function as a secondary level of gene regulation.
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