References
Query Results -- Details
MGI Accession ID: MGI:3590096
J Number: J:100954
Other Accession IDs:
Title: Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation.
Authors: Cheng IH; Palop JJ; Esposito LA; Bien-Ly N; Yan F; Mucke L
Journal: Nat Med
Volume: 10
Issue: 11
Date: 2004 Nov
Year: 2004
Pages: 1190-2
Review Status: Peer Reviewed
Abstract:
The Arctic mutation within the amyloid-beta (Abeta) peptide causes Alzheimer disease. In vitro, Arctic-mutant Abeta forms (proto)fibrils more effectively than wild-type Abeta. We generated transgenic mouse lines expressing Arctic-mutant human amyloid precursor proteins (hAPP). Amyloid plaques formed faster and were more extensive in Arctic mice than in hAPP mice expressing wild-type Abeta, even though Arctic mice had lower Abeta(1-42/1-40) ratios. Thus, the Arctic mutation is highly amyloidogenic in vivo.
Additional Information:
