References
Query Results -- Details
MGI Accession ID: MGI:3582937
J Number: J:99553
Other Accession IDs:
Title: Genetic regulation of light damage to photoreceptors.
Authors: LaVail MM; Gorrin GM; Repaci MA; Thomas LA; Ginsberg HM
Journal: Invest Ophthalmol Vis Sci
Volume: 28
Issue: 7
Date: 1987 Jul
Year: 1987
Pages: 1043-8
Review Status: Peer Reviewed
Abstract:
Albino mice of different inbred strains have been exposed to constant fluorescent lighting at an illuminance level of 115-130 ft-c for intervals of 1-6 weeks. Under these conditions the photoreceptors in retinas of albino BALB/cByJ mice rapidly degenerate, whereas the photoreceptors in retinas of albino C57BL/6J-c2J mice are remarkably more resistant to light damage. F1 heterozygotes produced from these two strains display an intermediate degree of light-induced degeneration. These findings demonstrate that phenotypically identical populations with different genetic constitutions can show markedly different sensitivities to light, and that genetic factors must now be included as a determinant for the severity of light damage.
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