References
Query Results -- Details
MGI Accession ID: MGI:3582029
J Number: J:99364
Other Accession IDs:
Title: Notch signals control the fate of immature progenitor cells in the intestine.
Authors: Fre S; Huyghe M; Mourikis P; Robine S; Louvard D; Artavanis-Tsakonas S
Journal: Nature
Volume: 435
Issue: 7044
Date: 2005 Jun 16
Year: 2005
Pages: 964-8
Review Status: Peer Reviewed
Abstract:
The Notch signalling pathway plays a crucial role in specifying cellular fates in metazoan development by regulating communication between adjacent cells. Correlative studies suggested an involvement of Notch in intestinal development. Here, by modulating Notch activity in the mouse intestine, we directly implicate Notch signals in intestinal cell lineage specification. We also show that Notch activation is capable of amplifying the intestinal progenitor pool while inhibiting cell differentiation. We conclude that Notch activity is required for the maintenance of proliferating crypt cells in the intestinal epithelium.
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