References
Query Results -- Details
MGI Accession ID: MGI:3581348
J Number: J:99151
Other Accession IDs:
Title: Requirement for Notch1 signals at sequential early stages of intrathymic T cell development.
Authors: Tan JB; Visan I; Yuan JS; Guidos CJ
Journal: Nat Immunol
Volume: 6
Issue: 7
Date: 2005 Jul
Year: 2005
Pages: 671-9
Review Status: Peer Reviewed
Abstract:
Signaling through the transmembrane Notch1 receptor directs thymus-seeding progenitors (TSPs) to suppress their B cell potential and 'choose' the T cell fate. Present paradigms suggest that TSPs are contained in the multipotent early T lineage precursor (ETP) subset of thymocytes. However, we show here that the B cell potential of ETPs was not augmented in microenvironments that limited Notch1 activation. Furthermore, low-threshold Notch1 signals suppressed B cell production by TSPs before they reached the ETP stage. Notch1 signals of a higher threshold were needed to drive proliferation of ETPs and development into CD4(+)CD8(+) double-positive thymocytes. Thus, TSPs can be differentiated from all previously identified early T cell progenitors by their robust B cell potential and exquisite sensitivity to Notch1 signals.
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